Euro Fed Lipid
Second European Symposium on Microbial Lipids (FEBS Workshop)
Microbial Lipids: Diversity in Structure and Function
16-19 May 2012, Bern, Switzerland

Main Topics

- Mitochondrial Lipids
- Lipid Dynamics and Trafficking
- Lipid Signalling
- Model Membranes
- Lipidomics
- Bacterial Lipids

Münster Bern. Source: Wikipedia, Author André P. Holzer

Call for Papers


Parliament Building Bern. Source Wikipedia, Author Raphael Frey

Scientific Committee

Peter Bütikofer, Bern, Switzerland (Chair)
Roger Schneiter, Fribourg, Switzerland
Andreas Conzelmann, Fribourg, Switzerland
Markus Aebi, Zürich, Switzerland


Wednesday, 16 May 2012

17:30 - 19:00
Arrival and Registration
19:00 - 19:10
Conference Opening
19:10 - 20:10
Chris Raetz Lecture
Chris Whitfield, University of Guelph
ABC transporters involved in the export of bacterial glycolipids
Session chair: Markus Aebi

Welcome Reception

Thursday, 17 May 2012

Session: Mitochondrial Lipids 1
Chair: Peter Bütikofer
08:30 - 09:05
Thomas Langer, University of Cologne, Germany 
Phospholipid Dynamics in Mitochondria
09:05 - 09:40
Benoît Kornmann, ETH Zürich, Switzerland
The Molecular Hug between the ER and the Mitochondria
09:40 - 10:00
Mauro Serricchio, Bern
An essential bacterial-type cardiolipin synthase mediates cardiolipin formation in a eukaryote
10:00 - 10:30
Coffee Break

Session: Mitochondrial Lipids 2
Chair: Roger Schneiter
10:30 - 11:05
Joost Holthuis, University of Utrecht, The Netherlands
Control of mitochondrial apoptosis by a putative ceramide sensor in the ER
11:05 - 11:30
V. Titorenko, Montreal
Lithocholic acid delays aging and exhibits a potent anti-cancer effect by altering mitochondrial composition, structure, metabolism, dynamics and function
11:30 - 12:00
Poster Session
12:30 - 13:45
13:45 - 14.30
Round Table Discussion on "Mitochondrial Lipids"

Session: Lipidomics
Chair: Andreas Conzelmann and Markus Aebi
14.30 - 15.05
Markus Wenk, National University of Singapore
Lipidomics of Host-pathogen Interactions
15.05 - 15.40
Fong-Fu Hsu, Washington University, St. Louis, MO/U.S.A. 
Structural Analyses of Microbial Lipids
15.40 - 16.10
Coffee Break
16.10 - 16.30
Felipe Gazos-Lopes, El Paso, USA
GPIomic analysis of the infective Trypanosoma cruzi trypomastigote life-stage
16.30 - 16.50
Aline X.S. Santos, Geneva, Switzerland
Yeast lipid homeostasis – new insights from a lipidomic screening of kinases and phosphatases
16.50 - 17.15
Vasyl Ivashov, Graz, Austria
Characterization of Pichia pastoris strains deficient in neutral lipid synthesis
Short Oral Poster Presentations
City Tour (Departure)
Dinner at the Restaurant Zunft zu Webern (Guild of Weavers) in the old town, Gerechtigkeitsgasse 68
(co-sponsored by the City and the Canton of Bern)
  Stadtplan  Bildsaal

Friday, 18 May 2012

Session: Lipid Dynamics and Traficking 1
Chair: Benoit Kornman
08:30 - 09:05
Todd Graham, Vanderbilt University, Nashville, TN/U.S.A. 
Probing the Phospholipid Flippase Giant Substrate Problem
09:05 - 09:40
Russ Bishop, McMaster University, Hamilton/ON, Canada
Lipid Acyl-chain Selection by the Membrane-intrinsic Enzyme PagP
09:40 - 10:00
Edina Harsay, Graz, Austria
Chemical probes and novel targets for modulating membrane traffic in cellular stress response
10:00 - 10:30
Coffee Break

Session: Lipid Dynamics and Trafficking 2
Chair: Scott Emr
10:30 - 11:05
Stephen Beverley, Washington University, St. Louis, MO/U.S.A.
Genetic manipulation of the Leishmania major Inositol Phorphoryl Ceramide Synthase
11:05 - 11:25
Angela Cadou, Lausanne, Switzerland
Nucleus-vacuole junctions in Saccharomyces cerevisiae: a role in lipid transfer between both organelles?
11:25 - 11:45
Markus Maniak, Kassel, Germany
The flow of a fatty acid through a Dictyostelium cell
11:45 - 12:15
Short Oral Poster Presentations
12:15 - 13:30
13:30 - 14:30
Poster Session
14.30 - 15.15
Round Table Discussion on "Lipidomics"
15:15 - 15:45
Coffee Break

Session: Bacterial Lipids  
Chair: Russell Bishop
15:45 - 16:20 Otto Holst, Leibniz Center for Medicine and Biosciences, Borstel, Germany
Structure and Function of Certain Bacterial Glycolipids
16:20 - 16:55
Yosuke Koga, Fukuoka/Japan 
Structures, biosynthesis and evolution of archaeal lipids, an overview
16:55 - 17:15
John E. Cronan, Urbana, IL/USA
The curious synthetic pathways of the modified fatty acid, lipoic acid
17:15 - 17:35
Joshua B. Parsons, Memphis, TN/USA
Perturbation of FabH activity confers resistance to FabF antibiotics

Saturday, 19 May 2012

Session: Lipid Signalling
Chair: Joost Holthuis
08:30 - 09:05
Scott Emr, Cornell University Ithaca, NY/USA
Regulation of phosphoinositide lipid signaling at PM-ER membrane contact sites
09:05 - 09:40
Jeremy Thormer, University of California, Berkeley, CA/USA
Plasma membrane sphingolipid-glycerolipid ratio is controlled by a protein kinase network
09:40 - 10:00
Robbie Loewith, Geneva
Sensing of plasma membrane stress mediated by lateral relocalization of Slm proteins activates TORC2
10:00 - 10:30
Coffee Break

Session: Model Membranes
Chair: Stephen Beverley
10:30 - 11:05
B. Antonny, University of Nice et CNRS, Valbonne, France
Osh4p senses membrane curvature and composition to exchange sterol for PI(4)P
11:05 - 11:25
John M. Harrington, Athens, GA/USA
Exploiting membrane fluidity in African trypanosomes
11:25 - 11:45
Vineet Choudhary, Fribourg, Switzerland
The pathogen related yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins
11:45 - 12:00
Closing Remarks


Mitochondrial Lipids

K. Gröne, Cologne/D
A Novel Function of the i-AAA Protease in Regulating the Mitochondrial Phospholipid Metabolism 
Lipid Dynamics and Trafficking

M. Sapiano, Hamilton/CDN
PagP Catalysis Proceeds through an Ordered Sequential Ternary Complex Reaction Mechanism.

K. Poloncova, Ivanka pri Dunaji/SK
Pdr16p and Lipid Metabolism of the Yeast Saccharomyces cerevisiae

Z. Simova, Ivanka pri Dunaji/SK
Pdr16p - Always One Step ahead

M. Connerth, Cologne/D
Ups1/PRELI-like Protein, a Novel Regulator of Mitochondrial Cardiolipin Biosynthesis

L. Farine, Bern/CH
Localization of Enzymes involved in Phosphatidylethanolamine Synthesis in Trypanosoma brucei

F. Mantzouridou, Thessaloniki/GR
Are Blakeslea trispora lipid globules only storage sites of carotenoids?

N.S. Voynova, Fribourg/CH
A Novel Pathway for Ceramide Metabolism in Saccharomyces Cerevisiae

R. Nagaraju, Fribourg/CH
Molecular And Functional Characterization Of S. Cerevisiae Ypc1p; An Yeast Alkaline Ceramidase And Its Topological Orientation Across the ER Membrane

Lipid Signalling

M.C. Pawlowic, Lubbock/USA
Sphingosine Kinase is a Vital Enzyme for Leishmania Survival and Pathogenesis

F. Martínez, Fribourg/CH
Regulation of Ergosterol Biosynthesis during the Adaptation to Osmotic Stress in the Yeast Saccharomyces cerevisiae.

Model Membranes

O.G. Weingart, Zürich/CH
Nerve-cell Mimicking Liposomes as in vitro Alternative to Potency-testing of Toxins with Multistep Pathways

N.A. Ghazaryan, Armenia/ARM
Giant Unilamellar Vesicles as an Ideal System for the sSudy of Interaction with Enzymatic Components of Venom

A. Torosyan, Yerevan/ARM
The Influence of Non-metal Porphyrins on Bilayer Lipid Membrane


R. Vitale, Bari/I
Lipidomics of Intact Mitochondria by MALDI-TOF/MS

A. Aguilera-Romero, Geneva/CH
Cross-talk between Signalling Pathways and Sphingolipid Metabolism: Looking for New Players in Sphingolipid Homeostasis

X.L. Guan, Basel/CH
Lipidomics of Host-pathogen Interactions: Human Macrophage as a Cellular System to Study Functional Implications of Lipid Metabolism during Infection

L. Lindberg, Gothenburg/S
Comparative Lipidomic Profiling of Saccharomyces cerevisiae to Reveal Lipid Composition Changes in the Plasma Membrane upon Exposure to Lignocellulose Inhibitors

Bacterial Lipids

I. Kolouchova, Prague/CZ
Structural Diversity of Mycolic Acids from Rhodococcus strains degrading Phenol in the Presence of Humic Acids by Liquid Chromatography-mass Spectrometry

P. Saenkham, Memphis/USA
Acyl-Acyl Carrier Protein Regulates Acetyl CoA Carboxylase in S. pneumoniae

M. Aktas, Bochum/D
New Insights into Biochemical Properties of Bacterial Phosphatidylcholine Biosynthesis Enzymes

R. Moser, Bochum/D
Biosynthesis and Role of Methylated Phospholipids for Bacterial Fitness and Microbe-plant-interactions

A. Tschumi, Zürich/CH
Functional Analyses of Mycobacterial Lipoprotein Diacylglyceryl Transferase and Comparative Secretome Analysis of a Mycobacterial lgt Mutant

A. Tschumi, Zürich/CH
A Mycobacterium tuberculosis Polyprenolmonophosphomannose Synthase (Ppm1) Mutant is Defective in Cell Wall Lipomannan and Moderately Attenuated in Mice

A. Corcelli, Bari/I
Novel Ether Lipid Cardiolipins in Archaeal Membranes of Extreme Haloalkaliphiles

S. Labasso, Bari/I
Polar Lipids of the Moderately halophilic Gram-positive Bacterium Halobacillus halophilus

K.A. Duda, Borstel/D
Structures of Glycolipids from Agrobacterium tumefaciens and Mesorhizobium loti Synthesized during Phosphate Deprivation

A.K. Bendt, Singapore/SGP
Mycolic Acids as Diagnostic Markers for Tuberculosis Case Detection and Drug Efficacy

Other Topics

R. Amache, London/GB
Quorum Sensing: Impact of various Oxylipins on Sporulation, Morphology and Secondary Metabolite Production in Penicillium Sclerotiorum

C. Schmidt, Graz/A
Regulatory Link between Non-polar Lipid Synthesis and Degradation in the Yeast Saccharomyces cerevisiae

V. Kh. Mamikonyan,Yerevan/ARM
Therapeutic Effectiveness of Grape Seeds Compounds with Antioxidant Activity

A. Gonzalez-Salgado, Bern/CH
myo-Inositol Uptake is Essential for Bulk Inositol Phospholipid Synthesis in Trypanosoma brucei

L.H. Faccioli, Ribeirão Preto/BR
Role of Prostaglandins in Host Defence during Histoplasma capsulatum Infection

A. Bochud, Fribourg/CH
Topology of the Yeast Phosphatidylinositol Synthase 1 (Pis1p), an Integral ER Membrane Protein

H.M. Vazquez de la Mora, Fribourg/CH
Epistatic Miniarray Profile (E-MAP) to ∼ 85% of all Proteins Predicted to have 2 or more Transmembrane Domains in S. Cerevisiae and Profile comparison with an E-MAP having Decreased Fatty Acid Content Induced by Cerulenin.

A. Bochud, Fribourg/ CH

Topology of the Yeast Glycerol-3-phosphate Acyltransferase GAT1

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